The effects of partial गंभीरता (example on मार्च) on our muscular system is still partly understood. Study in rats shows that resveratrol, a compound found in grape skin and red wine, can mitigate muscle impairment in a मार्च आंशिक गंभीरता model. This can be beneficial to sustain long-term मार्च मिशन।
राष्ट्रीय वैमानिकी और अंतरिक्ष प्रशासन (नासा) of USA is planning to send astronauts to Moon and मार्च. माइक्रोग्रैविटी को हमारे शरीर की पेशीय प्रणाली को प्रभावित करने के लिए जाना जाता है: मांसपेशियों and bones start to become weak. First, weight-bearing muscles like soleus, located in the calf are affected and then slow-twitch muscle fibers are lost. मंगल का gravitational pull is only 40 percent of Earth’s thus it has a lower gravity of 0.38g. It is still not completely understood how such आंशिक गुरुत्वाकर्षण can affect our body. No partial weight-bearing model has been tested until now which can mimic Martian partial gravity. More understanding in this area is critical in order to plan long space missions to मार्च and safe return of astronauts to Earth.
18 जुलाई को प्रकाशित एक नया अध्ययन फिजियोलॉजी के फ्रंटियर्स has used recently developed partial weight-bearing animal models of simulated मार्च partial gravity to understand how muscle deconditioning could be addressed on long मार्च space missions. To simulate gravity of मार्च, rats were fitted with full-body harness and were suspended from their cage ceiling. Divided into two groups, rats were exposed to normal loading (of Earth’s) or 40 percent loading of मार्च for 2 weeks. Half the number of rats in each group received either resveratrol (आरएसवी) - एक सुरक्षित पॉलीफेनोल आमतौर पर अंगूर की त्वचा, रेड वाइन और ब्लूबेरी में पाया जाता है - पानी या केवल पानी में। जानवरों को चाउ डाइट पर स्वतंत्र रूप से खिलाया जाता है।
In मार्च condition, rats’ grip weakened and their calf circumference, muscle weight and slow-twitch fiber content got shrunk. Calf circumference and front and rear paw grip force were measured weekly while calf muscles were analyzed after 2 weeks . Results showed that a moderate daily dose (150 mg/kg/day) of resveratrol was seen to preserve muscle mass and strength in animals exposed to the effects of a simulated मार्च gravity. RSV helped restore front and rear paw grips and protected muscle mass in मार्च rat while having no effect on diet or body weight. RSV is known to have anti-inflammatory, anti-oxidative and anti-diabetic effects. It has been shown to promote muscle growth in diabetic animals by increasing insulin sensitivity and glucose uptake in muscle fibers. Astronauts are thought of developing reduced insulin sensitivity during space missions.
Resveratrol is seen to have a muscle-protective effect as it preserves bone and muscle mass. The current study suggests that resveratrol can help to mitigate muscle impairment in a मार्च partial gravity analog which mimics मार्च environment. It could be used as a nutritional supplement to reduce muscle and skeletal deconditioning and deterioration on long-term मार्च मिशन।
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{आप उद्धृत स्रोतों की सूची में नीचे दिए गए डीओआई लिंक पर क्लिक करके मूल शोध पत्र पढ़ सकते हैं}
स्रोत (रों)
मॉर्ट्रेक्स, एम। 2019। रेस्वेराट्रोल की एक मध्यम दैनिक खुराक एक मार्टियन ग्रेविटी एनालॉग में मांसपेशियों की गिरावट को कम करती है। सामने। फिजियोल।
https://doi.org/10.3389/fphys.2019.00899
